He later served as Professor of Pharmacy at the College of Cincinnati and spent his life working with the Lloyd Library of Botany and Pharmacology.

He published works such as Chemistry of Drugs and Elixirs, compiled a pharmaceutical encyclopedia, and, as an editor, released numerous books on pharmacology.

His book Hytidorpha is considered his most significant work related to the concept of a journey to a “hollow earth,” and it is said to have influenced the “master of horror” writer H. P. Lovecraft.