After leaving his hometown, Fernando de Rojas moved to Talavera de la Reina, where he worked as a lawyer until his death in 1541.

He is known to have served briefly as mayor of the town and to have married Leonor Álvarez, with whom he had six children. Much of his later life remains shrouded in mystery and speculation, to the point that some have even questioned his existence.

He is believed to have studied law at the University of Salamanca for six years, and—according to tradition—wrote La Celestina, his only major work, in just fifteen days while still a student.